USMLE (Fach) / Biochemistry - Molecular, Cellular, Techniques (Lektion)

Vorderseite Splicing of pre-mRNA
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1. Primary transcript combines with small nuclear ribonucleoproteins (snRNPs) and other proteins to form spliceosome.2. Cleavage at 5' splice site; lariat-shaped (loop) intermediate is generated.3. Cleavage at 3' splice site; lariat is released to precisely remove intron and join 2 exons.

Antibodies to spliceosomal snRNPs (anti-Smith antibodies) are highly specific for SLE.

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