Deficiency of Th17 cells due to STAT3 mutation → defect in neutrophil chemotaxis

- Autosomal dominant

FATED:- Coarse facies- Staphylococcal abscesses (noninflamed)- Retained primary teeth- ↑ IgE- Dermatologic problems (severe eczema)- Bone fractures from minor trauma

Findings:- ↑ IgE, ↓ IFN-γ- ↑ eosinophils