Intravascular hemolysis:- ↓ haptoglobin, ↑ LDH, ↑ schistocytes, ↑ reticulocytes on blood smear.- Characteristic hemoglobulinuria, hemosiderinuria, and urobilinogen in urine.- May also see ↑ unconjugated bilirubin.- Causes: mechanical hemolysis (eg, prosthetic valve), paroxysmal nocturnal hemoglobulinuria, microangiopathic hemolytic anemias

Extravascular hemolysis:- Macrophages in spleen clear RBCs.- Spherocytes in peripheral smear (most commonly hereditary spherocytosis and autoimmune hemolytic anemia).- No hemoglobinuria/hemosiderinuria.- ↑ unconjugated bilirubin, which can cause jaundice.