USMLE (Fach) / Hematology and Oncology (Lektion)
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T cell
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Mediate cellular immune response.
- Originate from stem cells in the bone marrow, but mature in the thymus.
- Differentiate into cytotoxic T cells (express CD8, recognize MHC I), helper T cells (express CD4, recognize MHC II), and regulatory T cells .
- CD28 (costimulatory signal) necessary for T-cell activation.
- Most circulating lymphocytes are T cells (80%).
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