USMLE (Fach) / Hematology and Oncology (Lektion)
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B cells
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Part of humoral immune response.
- Originate from stem cells in bone marrow and mature in marrow.- Migrates to peripheral lymphoid tissue (follicles of lymph nodes, white pulp of spleen, unencapsulated lymphoid tissue)
- When antigen is encountered, B cells differentiate into plasma cells (which produce antibodies) and memory cells.
- Can function as APC via MHC II.
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