USMLE (Fach) / Hematology and Oncology (Lektion)
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Thrombocytes
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- Involved in 1° hemostasis- Small cytoplasmic fragments derived from megakaryocytes- Life span of 8-10 days- When activated by endothelial injury, aggregate with other platelets and interact with fibrinogen to form platelet plug
- Contain dense granules (ADP, Ca2+) and α granules (vWF, fibrinogen, fibronectin)Alfa granules contain vwF, fibrinogen, fibronectin
- Approximately 1/3 of platelet pool is stored in the spleen
- Thrombocytopenia or ↓ platelet function results in petechiae.- vWF receptor: GpIb- Fibrinogen receptor: GpIIb/IIIa- Thrombopoietin stimulates megakaryocyte proliferation.
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