USMLE (Fach) / Pharmacology - CNS (Lektion)

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- DOC for bipolar disorders

- usually antidepressants/antipsychotics also required

- prevents recycling of inositol (↓PIP2), ↓cAMP

- narrow therapeutic index (requires therapeutic monitoring)- tremor, flu-like symptoms, life-threatening seizures- hypothyroidism with goiter (↓TSH effects)- nephrogenic diabetes insipidus (↓ ADH effects)- teratogenicity: Ebstein's anomaly (malformed tricuspid valve)

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