Calcineurin inhibitor (like cyclosporine), binds FK506 binding protein.Blocks T-cell activation by preventing IL-2 transcription.

Use: Transplant rejection prophylaxis

Toxicity: Similar to cyclosporine (nephrotoxicity, hyperlipidemia, hypertension)- ↑ risk of diabetes and neurotoxicity- No gingival hyperplasia or hirsutism