USMLE (Fach) / Immunology (Lektion)

Vorderseite Common variable immunodeficiency
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Defect in B-cell differentiation. Cause unknown.

- Usually presents after age 2 and may be considerably delayed (age 25-35).

- Sinupulmonary infections- ↑ risk of autoimmune disease (eg, rheumatoid arthritis, ITP, vitiligo)- Bronchiectasis- ↑ risk of lymphoma

Findings:- ↓ plasma cells- ↓ immunoglobulins

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