Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate.- Nitroglycerin: sublingual, transdermal, IV- Isosorbide: oral, extended release for chronic use

Vasodilate by ↑ NO in vascular smooth muscle → ↑ cGMP and smooth muscle relaxation. - Dilate veins >> arteries. - ↓ preload

Clinical use: Angina, acute coronary syndrome, pulmonary edema.

Adverse effects:- Flushing, headache, orthostatic hypotension- "Monday disease" in industrial exposure: tolerance for the vasodilating action during the work week and loss of tolerance over the weekend → tachycardia, dizziness, headache- Reflex tachycardia (treat with β-blockers) - Contraindicated in right ventricular infarction.