- Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac, meloxicam, piroxicam

- Reversibly inhibit COX-1 and COX-2. Block prostaglandin synthesis

Clinical use:- antipyretic- analgesic- anti-inflammatory- Indomethacin is used to close PDA- Naproxen and indomethacin have uricosuric activity (in low doses)

Adverse effects:- Interstitial nephritis- Gastric ulcer (prostaglandins protect gastric mucosa)- Renal ischemia (prostaglandins vasodilate afferent arteriole)