Naked, dsDNA and circular

HPV – warts (serotypes 1, 2, 6, 11), CIN, cervical cancer (most commonly 16, 18)- Infects basal layer of the skin and mucous membranes- Malignancy may result: E6 and E7 inhibit tumor-suppressor genes p53 and Rb, respectively.

- HPV infects basal epithelial cells through small breaks in the skin or mucosal surfaces. It has a predilection for stratified squamous epithelium, which is found on the anal canal, vagina, cervix, true vocal cords in the respiratory tract.

- Koilocyte cells (cells with perinuclear cytoplasm vacuolization and nuclear enlargement) in Pap smears