USMLE (Fach) / Virology (Lektion)
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Rubella virus
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Togavirus (enveloped, ⊕ ssRNA)
Causes rubella, once known as German 3-day measles.
Presentation:- Low-grade fever- Postauricular and nuchal lymphadenopathy- Arthralgias- Fine, maculopapular, confluent rash that starts on face and spreads centrifugally to involve trunk and extremities.
Causes mild disease in children but serious congenital disease.
Congenital rubella findings:- Cataracts- Deafness- Cardiac defects- "Blueberry muffin" appearance due to dermal extramedullary hematopoiesis
- Live vaccine (with mumps and measles) at 12-15 months and again at 2 years old
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