USMLE (Fach) / Virology (Lektion)

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A flavivirus (enveloped, ⊕ ssRNA)- Arbovirus, transmitted by Aedes mosquito- Reservoir: Monkeys- Endemic in South America and Sub-Saharan Africa

Symptoms:1. High fever, headaches, chills, aching back2. Easing of symptoms and decline in fever3. Hemorrhage, multiorgan dysfunction, black vomitus, severe jaundice

Diagnosis:- May see Councilman bodies (eosinophilic apoptotic globules) on liver biopsy.- IgM antibodies, blood PCR in early illness

- Live-attenuated vaccine

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