USMLE (Fach) / Microbiology (Lektion)
Protazoa.Intestinal flagellate that exists in 2 forms: a trophozoite (pathogenic stage) or a cyst (infective stage). - The trophozoite is a bilaterally symmetric, pear-shaped oragnism with multiple flagella and 2 nuclei (owl's eyes appearance)- The cysts are oval and contain up to 4 nuclei.- Transmission: Cysts in water by drinking contaminated water (eg, campers, travelers).
Giardiasis – bloating, flatulence, foul-smelling, fatty diarrhea
- Multinucleated trophozoites or cysts in stool, antigen detection.- Small-bowel biopsy can show varying degrees of villus atrophy and crypt hyperplasia.
- Treatment: Metronidazole
- Children with IgA deficieny, X-linked agammagloulinemia, and CVID have a predisposition to chronic giardiasis.
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