Chagas disease – dilated cardiomyopathy with apical atrophy, megacolon, megaesophagus, achalasia.- Acute stage: Romaña sign (unilateral periorbital swelling).

- Predominantly in South America- Transmission: Reduviid bug ("kissing") bug, deposits feces in a painless bite

Diagnosis: Trypomastigote in blood smear

Therapy: Benznidazole or nifurtimox (cruzing in my Benz, with a fur coat on)