USMLE (Fach) / Microbiology (Lektion)
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Leptospira interrogans
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Spirochete with hook-shaped ends.- Zoonosis. - Found in water contaminated with animal urine.- Prevalent among surfers and in tropics (eg, Hawaii).
Leptospirosis- Flu-like symptoms - Myalgias (classically of calves)- Jaundice- Photophobia with conjunctival suffusion (erythema without exudate)
Weil disease (icterohemorrhagic leptospirosis)- Severe form with jaundice and azotemia- Liver and kidney dysfunction- Pulmonary hemorrhage → hemoptysis
Diagnosis: Serodiagnosis (agglutination test), culture (blood CSF, urine)
Treatment: Penicillin G or doxycycline
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