USMLE (Fach) / Biochemistry - Genetics (Lektion)
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Glucose 6-Phosphate Dehydrogenase Deficiency
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- X-linked recessive
- hemolytic anemia
- red blood cells contain a large amount of oxygen and are prone to spontaneously generate ROS that damage protein and lipid in the cell.
- In the presence of ROS, hemoglobin may precipitate (Heinz bodies)
- NADPH required by glutathione reductase is supplied by the HMP shunt
- increased resistance to malaria
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