USMLE (Fach) / Biochemistry - Genetics (Lektion)
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β-Thalassemia
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- deficiency of β-globin protein
- found primarily in Mediterranean areas (protects against malaria)
- splenomegaly due to the role of the spleen in clearing damaged red blood cells
- excessive activity of bone marrow produces bone deformities of the face and other areas
- long bones of the arms and legs fracture easily
- treatment: blood transfusions
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