USMLE (Fach) / Bones, Joints, and Soft Tissue Tumors (Lektion)
- chronic inflammatory disorder of autoimmune origin that principally attacks the joints producing synovitis
- F:M = 3:1
- positive for: rheumatoid factor, anti-CCP (citrullinated peptides) antibodies
- HLA-DR1 association
Joint- symmetric arthritis principally affecting small joints of the hand/feet- fibrous/bony ankylosisSkin- rheumatoid subcutaneous nodules (also in lungs & other organs) which resemble necrotizing granulomas
Clinical course:- begins with malaise, fatigue, musculoskeletal pain- symmetrical joint involvement- metacarpophalangeal and PIP joints, wrists, ankles, elbows, knees, upper spine (lumbosacral region & hips spared!)- swollen, warm, painful joints- stiff in the morning- decreased range of motion evolving to complete ankylosis- swan-neck deformity, boutonnière deformity- Baker cyst (herniation of the synovium)
Therapy: TNF-Antagonists
Diese Karteikarte wurde von estoffel erstellt.